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Post doctoral scientist in Enzyme engineering

This position will be part of a challenging project consisting in making new enzymes for glucose/O2 Biofuel cells. Biofuel cells are devices which convert chemical energy into electrical energy by means of enzymes. [1] The originality of this biofuel cell lies on the possibility to use it in physiological media and on its very small size which makes it eligible for applications requiring very small power source such as those encountered in microelectronics, and for direct use on the human body.

Specifically, the post doc researcher will characterize in depth the new cathodic enzyme that we recently identified [2] It is a bilirubin oxidase belonging to the MCO family, and is so far, the limiting component of the biofuel cell. Characterization will include spectroscopic studies, stopped flow experiments in aerobic or anaerobic conditions, identification of reaction intermediates and site-directed mutagenesis.

(1) Gao, F. ; Viry, L. ; Maugey, M. ; Poulin, P. ; Mano, N. Nat Commun 2010, 1, 10.1038/ncomms1000. (2) Mano, N. ; Mao, F. ; Heller, A. J Am Chem Soc 2003, 125, 6588. (3) Kjaergaard, C. H. ; Durand, F. ; Tasca, F. ; Qayyum, M. F. ; Kauffmann, B. ; Gounel, S. ; Suraniti, E. ; Hodgson, K. O. ; Hedman, B. ; Mano, N. ; Solomon, E. I. J Am Chem Soc 2012, 134, 5548. (4) Durand, F. ; Gounel, S. ; Kjaergaard, C. H. ; Solomon, E. I. ; Mano, N. Appl Microbiol Biotechnol 2012, 96, 1489.

The application, including CV, a statement of interest and academic references, should be sent to : Nicolas Mano : mano@crpp-bordeaux.cnrs.fr

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Applicants should have completed a PhD in Biology, Biochemistry or related fields and enjoy working in an interdisciplinary team. Experience with enzyme engineering, screening and structural biology notions would be a plus.

The “Centre de Recherche Paul-Pascal” (CRPP) was created in 1965 as a full CNRS Research Institute (UPR 8641) in the department of Chemical Sciences. It is recognized internationally and is one of the leading research center in France in the field of physical chemistry of soft condensed matter. Approximately 140 people work in the institute, distributed per third between technical staff, permanent Faculty and temporary researchers (undergraduate students, graduate students, PhD students, postdoctoral fellows, visitors,…). The laboratory is located on the campus of the University of Bordeaux I and takes part in the missions of teaching and research for the Department of Chemistry of this university.

[1] 1,2

[2] .3,4