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Droplet-based microfluidics for Synthetic Biology

PHD CHEMISTRY, STARTING FALL 2019, BORDEAUX, FRANCE

The origin of life is one of the most fascinating scientific problem. If matter managed to transition once (at least) from inanimate to living, what should be the conditions to observe this transition a second time ? It seems reasonable to consider that soft matter – through self-assembly and self-organization – played a role in the emergence of life. Given the experimental systems we have at hand currently and given our current understanding of the physical and chemical principles driving the behavior of living systems, can we construct artificial living systems from elementary ingredients and basic concepts ? Our ambition is to provide experimental systems usable to assemble life-like systems in a minimal approach. Our overarching technology is microfluidics. Here, we will focus on the functionalisation of microcompartments towards life-like systems targeting one essential functions of life : Metabolism. We will integrate metabolic functions into microcompartments to design new types of artificial organelles having biomimetic functions. This project will benefit from collaborations with the group of Tobias Erb at the Max Planck Institute for Terrestrial Microbiology (Marburg, D)

Student profile  : MASTER in PHYSICS, PHYSICAL CHEMISTRY or CHEMISTRY

PLEASE CONTACT (CV) :
- Jean-Christophe Baret
Centre de Recherche Paul Pascal (CRPP) UMR 5031
115 Av Schweitzer, 33600 Pessac, FRANCE ;
E-mail : Jean-Christophe Baret ; Tél : 05 56 84 56 34