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TrypanoFluidics : Variability of enzymatic response in population of Trypanosomes

PHD CHEMISTRY, STARTING FALL 2017, BORDEAUX, FRANCE

Trypanosomes are parasites infecting mammals with severe therapeutic and economic consequences in african countries. While it is known that during trypanosome infection suddent changes of membrane proteins are responsible for the adaptation of the parasite to the immune system response, very little is known on the variability in trypanosome activity in the blood. One of the mechanism of action of the trypanosome is mediated by the release of Phospholipase in the blood stream causing damages to the red blood cell. We want to provide quantitative measurements of the activity of trypanosomes at the single cell level for a deeper understanding of the dynamics of the disease.

Student profile : Chimie / Biochimie

PLEASE CONTACT (CV) :
Jean-Christophe Baret Centre de Recherche Paul Pascal UPR CNRS 8641
115 Av Schweitzer, 33600 Pessac, FRANCE
Tel : +33 (0)5 56 84 56 34

Loïc Rivière Microbiologie Fondamentale et Pathogénicité UMR CNRS-5234, Université de Bordeaux 146 rue Léo Saignat, 33076 Bordeaux Cedex, FRANCE
Tel : +33 (0)5 57 57 48 39